BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Doheny Eye Institute - ECPv6.15.16//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://doheny.org X-WR-CALDESC:Events for Doheny Eye Institute REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20190310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20191103T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20200308T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20201101T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20210314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20211107T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20220313T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20221106T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20230312T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20231105T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20240310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20241103T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20250309T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20251102T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20260308T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20261101T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20270314T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20271107T090000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260410T120000 DTEND;TZID=America/Los_Angeles:20260410T130000 DTSTAMP:20260825T035746 CREATED:20251001T192909Z LAST-MODIFIED:20260414T192650Z UID:10000253-1775822400-1775826000@doheny.org SUMMARY:Distinguished Lecture Series April 2026 — Vladimir Kefalov\, PhD DESCRIPTION:Distinguished Lecture Series April 2026 — Vladimir Kefalov\, PhD\n \n \n \n \n \n Our 2026 Doheny Distinguished Lecture Series (DLS) April lecture was delivered by Vladimir Kefalov\, PhD\, on Friday\, April 10\, 2026. Please refer to the lecture details below. \n\nDate: 4/10/26\nDLS Speaker: Vladimir Kefalov\, PhDProfessor\, OphthalmologyProfessor\, Physiology & BiophysicsUniversity of California\, IrvineGavin Herbert Eye Institute\nPresentation Title: “Understanding Cone Dark Adaptation”\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Vladimir J. Kefalov\, PhD investigates how rod and cone photoreceptors function\, adapt to light and dark\, and degenerate in disease. His lab explores phototransduction\, calcium signaling\, and the visual cycle (especially chromophore turnover) in healthy and mutant retinas. In recent high-impact work\, he and colleagues published a comprehensive review on the retina-based visual cycle\, highlighting how Müller glia supplement the canonical RPE pathway to regenerate cone pigments rapidly and sustain daylight vision. URL:https://doheny.org/event/distinguished-lecture-series-april-2026-vladimir-kefalov-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/10/Doheny-DLS-Vladimir-Kefalov_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260325T120000 DTEND;TZID=America/Los_Angeles:20260325T130000 DTSTAMP:20260825T035746 CREATED:20251001T192004Z LAST-MODIFIED:20260414T192639Z UID:10000252-1774440000-1774443600@doheny.org SUMMARY:Distinguished Lecture Series March 2026 — Aaron Lee\, MD\, MSCI DESCRIPTION:Distinguished Lecture Series March 2026 — Aaron Lee\, MD\, MSCI\n \n \n \n \n \n Our 2026 Doheny Distinguished Lecture Series (DLS) March lecture will be delivered by Aaron Lee\, MD\, MSCI\, on Wednesday\, March 25\, 2026. Please refer to the lecture details below. \n\nDate: 3/25/26\nDLS Speaker: Aaron Lee\, MD\, MSCIChair and Arthur W. Stickle Distinguished ProfessorJohn F. Hardesty\, MD\, Department of Ophthalmology & Visual SciencesWashington University School of Medicine\, St. Louis\nPresentation Title: “Deep Learning Applications in Ophthalmology: The Past\, Present\, and Future”\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. Aaron Y. Lee is a physician-scientist whose research bridges ophthalmology and artificial intelligence / computational medicine. He develops interpretable\, generalizable AI and deep learning models that integrate multimodal health data (e.g.\, retinal imaging + EHRs) to detect eye disease and systemic conditions. In his most recent high-impact work\, he is co-leading AI-READI\, an ethically governed\, multimodal dataset initiative for type 2 diabetes intended to power fair\, transparent AI investigations across diverse populations. URL:https://doheny.org/event/distinguished-lecture-series-march-2026-aaron-lee-md-msci/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/10/Doheny-DLS-Aaron-Lee_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260227T120000 DTEND;TZID=America/Los_Angeles:20260227T130000 DTSTAMP:20260825T035746 CREATED:20250925T204726Z LAST-MODIFIED:20260414T192624Z UID:10000251-1772193600-1772197200@doheny.org SUMMARY:Distinguished Lecture Series February 2026 — David Gamm\, MD\, PhD DESCRIPTION:Distinguished Lecture Series February 2026 — David Gamm\, MD\, PhD\n \n \n \n \n \n Our 2026 Doheny Distinguished Lecture Series (DLS) February lecture was delivered by David Gamm\, MD\, PhD\, on Friday\, February 27\, 2026. Please refer to the lecture details below. \n\nDate: 2/27/26\nDLS Speaker: David Gamm\, MD\, PhDProfessor of Ophthalmology and Visual SciencesUniversity of Wisconsin School of Medicine and Public Health\nPresentation Title: “Designing Stem Cell-Based Potency Assays to Advance Retinal Gene Therapies”\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. David M. Gamm’s work focuses on harnessing human pluripotent stem cell technologies to understand and treat retinal degenerative diseases. His lab creates “mini-retinas” or three-dimensional retinal tissues in vitro\, containing functional photoreceptors\, to model human retinal development and disease. In his more recent seminal work\, he explores cell- and gene-based therapies to replace or preserve photoreceptors in conditions like retinitis pigmentosa\, macular degeneration\, Usher syndrome\, and Choroideremia. URL:https://doheny.org/event/distinguished-lecture-series-february-2026-david-gamm-md-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/09/Doheny-DLS-David-Gamm_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20260109T120000 DTEND;TZID=America/Los_Angeles:20260109T130000 DTSTAMP:20260825T035746 CREATED:20250925T204722Z LAST-MODIFIED:20260414T192606Z UID:10000250-1767960000-1767963600@doheny.org SUMMARY:Distinguished Lecture Series January 2026 — Connie Cepko\, PhD DESCRIPTION:Distinguished Lecture Series January 2026 — Connie Cepko\, PhD\n \n \n \n \n \n Our 2026 Doheny Distinguished Lecture Series (DLS) January lecture was delivered by Connie Cepko\, PhD\, on Friday\, January 9\, 2026. Please refer to the lecture details below. \n\nDate: 1/9/26\nDLS Speaker: Connie Cepko\, PhDBullard Professor of Genetics and NeuroscienceHarvard Medical SchoolInvestigator\, Howard Hughes Medical Institute\nPresentation Title: “Gene-Agnostic Gene Therapy to Preserve Vision”\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Constance “Connie” Cepko\, PhD\, studies how the vertebrate retina develops and degenerates\, especially probing the molecular and cellular mechanisms that direct cell fate\, survival\, and neural circuitry in the eye. In her recent\, high-impact work\, she has advanced gene-agnostic therapies for inherited retinal disease\, for example\, delivering the MCT2 transporter via viral vectors to retinal pigment epithelium to sustain cone survival in retinitis pigmentosa models. URL:https://doheny.org/event/distinguished-lecture-series-january-2026-connie-cepko-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/09/Doheny-DLS-Connie-Cepko_Page-Topper-2.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250425T120000 DTEND;TZID=America/Los_Angeles:20250425T130000 DTSTAMP:20260825T035746 CREATED:20250226T010458Z LAST-MODIFIED:20250530T171914Z UID:10000240-1745582400-1745586000@doheny.org SUMMARY:Distinguished Lecture Series April 2025 — Julia Busik\, PhD\, FARVO DESCRIPTION:Diabetic Retinopathy as Ceramidopathy: A Lipocentric Approach to a Glucocentric Problem\n \n \n \n \n \n Our 2025 Doheny Distinguished Lecture Series (DLS) April lecture was delivered by Julia Busik\, PhD\, FARVO\, on Friday\, April 25\, 2025. Please refer to the lecture details below. \n\nDate: 4/25/25\nDLS Speaker: Julia Busik\, PhD\, FARVOEd Miller Endowed Chair\, Professor and Chair of the Department of Biochemistry and Physiology at the University of Oklahoma Health Sciences Center.\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. Julia Busik is a Professor and Chair of the Department of Biochemistry and Physiology at the University of Oklahoma Health Sciences Center\, where she holds the Ed Miller Endowed Chair. Her research focuses on the metabolic and inflammatory mechanisms underlying diabetic retinopathy (DR)\, with a particular emphasis on the role of lipid dysregulation and ceramide signaling in retinal vascular dysfunction. Her pioneering work has significantly improved our understanding of DR pathogenesis while simultaneously identifying novel therapeutic targets for management of retinal vascular complications. Dr. Busik’s research\, which has been continuously funded by the National Institutes of Health (NIH) and various private foundations\, has resulted in 80 peer-reviewed publications that have been cited over 5\,000 times with an h-index of 43. \nBeyond her research\, Dr. Busik is a dedicated mentor and educator\, having trained multiple Ph.D. students and postdoctoral fellows in molecular physiology and vision research. She has been recognized for her contributions with several prestigious awards\, including the Gold Fellow distinction from ARVO and multiple institutional honors for research excellence and faculty mentorship. Dr. Busik earned her Ph.D. in Physiology from the Graduate University for Advanced Studies in Yokohama\, Japan\, and completed her early research training at the National Institute for Physiological Sciences in Japan. Before joining the University of Oklahoma\, she held faculty positions at Michigan State University\, where she led significant research initiatives in diabetic eye disease. URL:https://doheny.org/event/distinguished-lecture-series-april-2025-julia-busik-phd-farvo/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/02/Doheny-DLS-Busik_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250325T120000 DTEND;TZID=America/Los_Angeles:20250325T130000 DTSTAMP:20260825T035746 CREATED:20250214T205844Z LAST-MODIFIED:20250410T235223Z UID:10000239-1742904000-1742907600@doheny.org SUMMARY:Distinguished Lecture Series March 2025 — Robert Mullins\, MS\, PhD DESCRIPTION:You Need to Calm Down: Complement Overactivity in Age-related Macular Degeneration\n \n \n \n \n \n Our 2025 Doheny Distinguished Lecture Series (DLS) March lecture was delivered by Robert Mullins\, MS\, PhD\, on Tuesday\, March 25\, 2025. Please refer to the lecture details below. \n\nDate: 3/25/25\nDLS Speaker: Robert Mullins\, MS\, PhDMartin Carver Chair in Ocular Cell Biology and Professor of Ophthalmology and Visual Sciences at The University of Iowa Carver College of Medicine.\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. Robert F. Mullins is a Professor in the Department of Ophthalmology and Visual Sciences at The University of Iowa\, where he holds the Martin Carver Chair in Ocular Cell Biology. His research focuses on the molecular and cellular mechanisms underlying age-related macular degeneration (AMD)\, choroidal endothelial dysfunction\, and retinal diseases\, with a particular emphasis on the role of the complement system and extracellular matrix abnormalities in the aging eye. His pioneering work has significantly contributed to the understanding of AMD pathophysiology\, leading to novel therapeutic strategies for macular degeneration and inherited retinal diseases. Dr. Mullins’ research has been funded by the NIH\, Macula Vision Research Foundation\, and multiple other prestigious funding bodies. He has authored over 190 peer-reviewed publications\, many of which have been instrumental in shaping the field of ocular disease research. His work has provided critical insights into choriocapillaris vascular dysfunction\, gene expression in the human retina and choroid\, and potential gene therapy interventions. \nIn addition to his research\, Dr. Mullins is a dedicated mentor and educator\, having trained numerous Ph.D. and M.D./Ph.D. students in genetics\, biomedical engineering\, and molecular medicine. His contributions to scientific service and peer review include roles as Associate Editor for Progress in Retinal and Eye Research\, an Editorial Board Member for Investigative Ophthalmology & Visual Science\, and a reviewer for major funding organizations such as the NIH\, Macula Society\, and BrightFocus Foundation. He is also Treasurer for the International Society for Eye Research (ISER). Dr. Mullins earned his Ph.D. in Cell and Molecular Biology from Saint Louis University and completed his postdoctoral fellowship at The University of Iowa Center on Aging. He joined the faculty at Iowa in 2001 and has since established himself as a leader in retinal research. Recognized for his contributions\, he has received numerous honors\, including the David F. Weeks Award for Outstanding AMD Research\, the Ashton Memorial Lecture Award\, and multiple ARVO Fellow (FARVO) distinctions. His commitment to advancing the understanding and treatment of retinal diseases continues to drive innovation in the field of ophthalmology. \n \n REGISTER NOW URL:https://doheny.org/event/doheny-distinguished-lecture-series-february-2025-robert-mullins-ms-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2025/02/Doheny-DLS-Mullins_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20250207T120000 DTEND;TZID=America/Los_Angeles:20250207T130000 DTSTAMP:20260825T035746 CREATED:20241210T211041Z LAST-MODIFIED:20250410T235151Z UID:10000238-1738929600-1738933200@doheny.org SUMMARY:Doheny Distinguished Lecture Series February 2025 — Rajendra Apte\, MD\, PhD DESCRIPTION:Marching Upstream: The Battle Against Age-Related Macular Degeneration\n \n \n \n \n \n Our 2025 Doheny Distinguished Lecture Series (DLS) February lecture was delivered by Rajendra Apte\, MD\, PhD\, on Friday\, February 7\, 2025. Please refer to the lecture details below. \n\nDate: 2/7/25\nDLS Speaker: Rajendra Apte\, MD\, PhDPaul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences\, Vice Chair for Innovation and Translation\, and Professor of Developmental Biology and Medicine at Washington University in St. Louis.\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. Rajendra Apte is the Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences at Washington University in St. Louis. He is also the Vice Chair for Innovation and Translation and holds professorial roles in the Departments of Developmental Biology and Medicine. His research focuses on the molecular mechanisms underlying retinal diseases such as age-related macular degeneration (AMD)\, diabetic retinopathy\, and retinal vascular diseases. Dr. Apte’s pioneering work has elucidated how immune dysfunction\, aging\, and lipid metabolism contribute to retinal degeneration\, leading to novel therapeutic strategies. His lab has been continuously funded by the NIH\, Research to Prevent Blindness (RPB)\, the Jeffrey T. Fort Innovation Fund\, the Siteman Retina Research Fund\, and the Starr Foundation\, among others. He has authored more than 175 research and review articles\, which have been extensively cited. \nIn addition to his research\, Dr. Apte is internationally recognized for his clinical and surgical retinal expertise. His innovations have informed the development of key treatments for AMD and diabetic retinopathy\, particularly those targeting VEGF and inflammation. A recipient of numerous accolades\, Dr. Apte’s honors include the Roger H. Johnson AMD Award\, the Ernst Bárány Prize\, the UT Southwestern Wayne Streilein Distinguished Alumnus Award\, the Macula Society Richard Green and Young Investigator Awards\, the President’s Award from the American Society of Retina Specialists\, and multiple RPB awards. An esteemed educator\, he has trained many leading retina specialists and is deeply committed to mentoring the next generation of clinician-scientists. \nDr. Apte obtained his medical degree from the University of Bombay\, his PhD in Immunology\, and completed his residency training at the University of Texas Southwestern Medical Center. He completed his vitreoretinal fellowship at the Wilmer Eye Institute at Johns Hopkins University. He joined the faculty at Washington University in 2003 and became a tenured\, distinguished professor in less than 10 years. He has also started multiple biotech companies. \n \n REGISTER NOW URL:https://doheny.org/event/dls-february-2025/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2024/12/Doheny-DLS-Apte_Page-Topper.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241213T120000 DTEND;TZID=America/Los_Angeles:20241213T130000 DTSTAMP:20260825T035746 CREATED:20241119T202525Z LAST-MODIFIED:20250117T002315Z UID:10000237-1734091200-1734094800@doheny.org SUMMARY:Doheny Distinguished Lecture Series December 2024 — David R. Williams\, PhD DESCRIPTION:Seeing Through Retinal Ganglion Cells\n \n \n \n \n \n Our 2024 Doheny Distinguished Lecture Series (DLS) December lecture was delivered by David R. Williams\, PhD\, on Friday\, December 13\, 2024. Please refer to the lecture details below. \n\nDate: 12/13/24\nDLS Speaker: David R. Williams\, PhDWilliam G. Allyn Endowed Professor of Medical OpticsDirector\, Center for Visual Science\, University of Rochester\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, 2nd Floor Conference Room\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr. Williams received his Ph.D. in psychology from the University of California\, San Diego\, in 1979. Following a postdoctoral fellowship at Bell Laboratories\, Murray Hill\, he joined the University of Rochester faculty in 1981. Dr. Williams’ research program marshals advanced optical technology to address questions about vision in the normal and diseased eye. His research team demonstrated the first adaptive optics system for the eye\, showing that vision in the laboratory can be improved beyond that provided by conventional spectacles. This work was instrumental in the development of wavefront sensors that can provide a complete description of the eye’s aberrations and are now used to improve vision correction technologies such as spectacles\, contact lenses\, intraocular lenses\, and refractive surgery. His group also demonstrated the first closed-loop adaptive optics ophthalmoscope\, which can image the normal and diseased retina at a microscopic\, cellular spatial scale. An early application of this technology revealed the topography of all three cone classes in the living human retina. \nMore recently\, Dr. Williams and his colleagues have deployed adaptive optics to improve our understanding of the role played by retinal processing in vision\, having developed a method to optically record from retinal ganglion cells and also to optogenetically drive ganglion cell responses with light in the living primate eye. For nearly three decades\, until 2021\, Dr. Williams served as director of the University of Rochester’s Center for Visual Science\, an interdepartmental program of 45 faculty researchers invested in vision science and ophthalmology. From 2011–2019\, Dr. Williams also served as Dean for Research in Arts\, Sciences\, and Engineering. Awards include the Edgar G. Tillyer Award\, the Friedenwald Award\, the Bressler Prize\, the Champalimaud Vision Award\, the Beckman Argyros Award\, the RPB David F. Weeks Award for Outstanding Vision Research\, and the Rank Prize in Optoelectronics. He is a member of the National Academy of Inventors and the National Academy of Sciences. URL:https://doheny.org/event/dls-december-2024/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2024/11/Doheny-DLS-David-R-Williams_Page-Topper_01.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240403T120000 DTEND;TZID=America/Los_Angeles:20240403T133000 DTSTAMP:20260825T035746 CREATED:20231130T002135Z LAST-MODIFIED:20241106T214357Z UID:10000220-1712145600-1712151000@doheny.org SUMMARY:Doheny Distinguished Lecture Series April 2024 — Christine Curcio\, PhD DESCRIPTION:The x\,y\,z\,t of age-related macular degeneration and the possibility of precision prevention\n \n \n \n \n \n Our 2023-24 Doheny Distinguished Lecture Series (DLS) April lecture will be delivered by Christine Curcio\, PhD\, on Wednesday\, April 3\, 2024. Please refer to the lecture details below. \n\nDate: 4/3/24\nDLS Speaker: Christine Curcio\, PhDWhite-McKee Endowed Professor of Ophthalmology (2018-2024)\, Heersink School of Medicine\, The University of Alabama at Birmingham\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, Conference Center\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Christine Curcio\, PhD is a world-renowned vision researcher who has made seminal contributions to our understanding of the anatomic and molecular pathobiology of age-related macular degeneration (AMD)\, the leading cause of vision loss in aged adults. Using tools of digital histology\, her lab has made important discoveries regarding the composition and role of drusen deposits in human AMD while also identifying other key hallmarks of the disease such as photoreceptor loss\, gliosis\, and RPE transdifferentiation. These findings have formed the basis for both mechanistic investigations into AMD pathogenesis and improved clinical diagnosis of AMD worldwide. Dr. Curcio’s research has been supported by multiple NIH grants and foundations. She has logged >250 PubMed entries\, >32\,000 citations\, and an H-index of 82. For her contributions to vision research\, Dr. Curcio has received several awards including the 2002 (inaugural) Roger H. Johnson Prize for Macular Degeneration research\, 2014 Ludwig von Sallmann Prize\, 2020 Research to Prevent Blindness – David F. Weeks Award\, and the 2022 Lawrence A. Yannuzzi Lectureship of the International Retinal Imaging Society. \nIn 2022\, she became a Laureate of the Future Vision Foundation. Dr. Curcio earned her PhD from the University of Wisconsin-Madison and the University of Rochester and did postdoctoral training at Boston University and the University of Washington-Seattle before joining the faculty of the University of Alabama at Birmingham in 1990\, from which she recently retired to become a private consultant and visiting faculty. \n \n REGISTER NOW URL:https://doheny.org/event/dls-april2024/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2023/11/DEI-Christine-Curcio-DLS-2.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240216T120000 DTEND;TZID=America/Los_Angeles:20240216T133000 DTSTAMP:20260825T035746 CREATED:20231130T001731Z LAST-MODIFIED:20240328T223043Z UID:10000219-1708084800-1708090200@doheny.org SUMMARY:Doheny Distinguished Lecture Series February 2024 — Lois Smith\, MD\, PhD DESCRIPTION:Can we prevent retinopathy by improving mitochondrial metabolism?\n \n \n \n \n \n Our 2023-24 Doheny Distinguished Lecture Series (DLS) February lecture will be delivered by Lois Smith\, MD\, PhD\, on Friday\, February 16\, 2024. Please refer to the lecture details below. \n\nDate: 2/16/24\nDLS Speaker: Lois Smith\, MD\, PhDProfessor of Ophthalmology at Boston Children’s Hospital and Harvard Medical School\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, Conference Center\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nBio:Dr Lois Smith is a renowned clinician scientist who has made seminal contributions to our understanding and treatment of blinding retinal diseases such as retinopathy of prematurity\, age-related macular degeneration\, and diabetic retinopathy. She pioneered the study of oxygen-induced retinopathy that affects many premature infants and identified crucial roles for VEGF\, growth hormones\, and IGF-1 in pathological neovascularization associated with this vision-threatening condition. Dr Smith’s research also identified a previously unrecognized role for the omega-3 and omega-6 fatty acids in pathological neovascularization. More recently\, she has been investigating the role of photoreceptor metabolism in ischemia-induced neovascularization. Her lab has been continuously supported by multiple NIH grants. For her seminal contributions to vision research\, Dr Smith has received numerous awards including the Alcon Research Institute Award\, the Friedenwald Award from ARVO\, the Silverman Award\, and the Bressler Prize in Vision Science from Lighthouse Guild. In 2023\, she received an honorary doctorate from the University of Montreal. Dr Smith earned her PhD from Caltech and her MD from Boston University before doing her residency at Mass Eye and Ear Infirmary and a fellowship at Boston Children’s Hospital\, where she has remained since. URL:https://doheny.org/event/dls-february2024/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2023/11/Lois_Smith2.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:rsvp@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240112T120000 DTEND;TZID=America/Los_Angeles:20240112T130000 DTSTAMP:20260825T035746 CREATED:20231130T000534Z LAST-MODIFIED:20240328T223240Z UID:10000218-1705060800-1705064400@doheny.org SUMMARY:Doheny Distinguished Lecture Series January 2024 featuring Maureen Neitz\, PhD DESCRIPTION:Our 2023-24 Doheny Distinguished Lecture Series (DLS) January lecture will be delivered by Maureen Neitz\, PhD\, on January 12\, 2024 presenting “Genetic discoveries that led to the contrast theory of myopia and the development of Diffusion Optic Technology spectacles” \nDate: 1/12/24DLS Speaker: Maureen Neitz\, PhDRay and Grace Hill Endowed Chair in Ophthalmology and Director of Graduate Program in Neuroscience at the University of WashingtonTime: 12:00 – 1:30 pmLocation: Doheny Eye Institute\, Conference Center\, 150 North Orange Grove Blvd.\, Pasadena\, CA \nBio:Dr Maureen Neitz is a vision scientist whose research includes work on color vision\, gene therapy\, and the prevention of nearsightedness. She holds the Ray and Grace Hill Endowed Chair in Ophthalmology at the University of Washington and serves as the director of the UW Graduate Program in Neuroscience and the NEI P30 funded Vision Research Core. Dr Neitz earned a PhD in biochemistry and molecular biology from UC Santa Barbara in 1986. After continuing at UC Santa Barbara as a postdoctoral fellow\, she joined the faculty at the Medical College of Wisconsin in 1991. She moved to the University of Washington in 2009. Dr Neitz is married to and works with Jay Neitz\, also a vision scientist. They have been successfully collaborating in studies of the visual system from genes to behavior since 1986. URL:https://doheny.org/event/dls-january2024/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2023/11/Maureen_Neitz-e1702575276759.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:rsvp@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20231211T120000 DTEND;TZID=America/Los_Angeles:20231211T133000 DTSTAMP:20260825T035746 CREATED:20231129T235633Z LAST-MODIFIED:20240328T223714Z UID:10000216-1702296000-1702301400@doheny.org SUMMARY:Doheny Distinguished Lecture Series December 2023 featuring Valerio Carelli and Chiara La Morgia DESCRIPTION:We are pleased to announce that the first lecture in the 2023-24 Doheny Distinguished Lecture Series (DLS) will be delivered by Valerio Carelli\, MD\, PhD\, Chief of the Laboratory of Neurogenetics at the University of Bologna School of Medicine\, on Dec 11. Please refer to the lecture details below. \n\nDate: 12/11/2023\nDLS Speaker: Dr. Valerio Carelli\, MD\, PhD\n\nWith a co-presentation by Dr. Chiara La Morgia\, PhD \n\nTitle: NAD(P)H oxidoreductase I (NQO1) and its implications for Leber hereditary optic neuropathy (LHON) treatment\nTime: 12:00 – 1:00 pm\nLocation: Doheny Eye Institute\, Conference Center\, 150 North Orange Grove Blvd.\, Pasadena\, CA\n\nZoom Details: For those unable to attend in person\, please click the register box below to secure your virtual seat. \nKindly register with your first and last name to ensure smooth access to the virtual meeting. Once registered\, you will receive a Zoom invite containing the meeting ID and passcode. We look forward to your participation in this distinguished lecture and the opportunity to explore advancements in LHON treatment. URL:https://doheny.org/event/dls-december2023/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/png:https://doheny.org/wp-content/uploads/2023/11/DLS-Carelli.png ORGANIZER;CN="Doheny Eye Institute":MAILTO:rsvp@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230407T120000 DTEND;TZID=America/Los_Angeles:20230407T130000 DTSTAMP:20260825T035746 CREATED:20220909T203158Z LAST-MODIFIED:20221102T175007Z UID:10000200-1680868800-1680872400@doheny.org SUMMARY:Distinguished Lecture Series - Alzheimer’s Disease Landscape in The Retina DESCRIPTION:Description\nDr. Maya Koronyo-Hamaoui is Professor of Neurosurgery and Professor of Biomedical Sciences at Cedars-Sinai\, Los Angeles. Her primary research focus is on early diagnosis and immune-based therapies for Alzheimer’s disease (AD). The Koronyo-Hamaoui Laboratory has shown that the hallmark pathologies of AD\, amyloid-β protein (Aβ) plaques and neurofibrillary tangles (NFTs)\, along with inflammation and neuronal degeneration are present in the retina and mirroring brain pathology in human patients\, beginning at early stages. A unique approach has been developed in her lab to detect amyloid plaques in the retina of living animal models and patients by a noninvasive optical retinal imaging. This innovation unveils new possibilities for investigation of Alzheimer’s pathology in the retina. It may also facilitate early diagnosis and noninvasive monitoring of disease progression. URL:https://doheny.org/event/distinguished-lecture-series-maya-koronyo-hamaoui-phd-2-2/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2022/08/1920_koronyomayaresearch22014-1.jpg ORGANIZER;CN="Janet DeMint & Kaustabh Ghosh%2C PhD":MAILTO:jdemint@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230407T120000 DTEND;TZID=America/Los_Angeles:20230407T130000 DTSTAMP:20260825T035746 CREATED:20220909T200927Z LAST-MODIFIED:20230315T225659Z UID:10000209-1680868800-1680872400@doheny.org SUMMARY:Distinguished Lecture Series - Maya Koronyo-Hamaoui\, PhD DESCRIPTION:Description\n \n \n \n \n \n Dr. Maya Koronyo-Hamaoui is Professor of Neurosurgery and Professor of Biomedical Sciences at Cedars-Sinai\, Los Angeles. Her primary research focus is on early diagnosis and immune-based therapies for Alzheimer’s disease (AD). The Koronyo-Hamaoui Laboratory has shown that the hallmark pathology of AD\, amyloid-β protein (Aβ) plaque\, is present in the retina of human patients beginning at early stages. A unique approach has been developed in her lab to detect plaques in the retina of live rodent models by a noninvasive optical retinal imaging. This innovation unveils new possibilities for investigation of Alzheimer’s pathology in the retina. It may also facilitate early diagnosis and noninvasive monitoring of disease progression. \nMaya Koronyo-Hamaoui and collaborators at Cedars-Sinai Medical Center including Alexander Ljubimov\, produced the most extensive analysis to date of retinal changes in people with Alzheimer’s disease. Their analysis also shows how these changes correspond to brain and cognitive changes. For more information visit Read more here URL:https://doheny.org/event/distinguished-lecture-series-maya-koronyo-hamaoui-phd-2/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/png:https://doheny.org/wp-content/uploads/2022/09/DLS-Maya-Koronyo.png ORGANIZER;CN="Janet DeMint & Kaustabh Ghosh%2C PhD":MAILTO:jdemint@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20230203T120000 DTEND;TZID=America/Los_Angeles:20230203T130000 DTSTAMP:20260825T035746 CREATED:20220620T235608Z LAST-MODIFIED:20230306T220539Z UID:10000188-1675425600-1675429200@doheny.org SUMMARY:A Tale of Two Drugs: Developing Novel Therapeutics to Treat Glaucoma - Michael Fautsch\, PhD DESCRIPTION:Abstract\n \n \n \n \n \n Over the past decade\, our laboratory has focused on understanding how pharmacological agents used in glaucoma therapy lower IOP\, with the belief that understanding how IOP is lowered can lead to the identification of candidate molecules that can be utilized for future targeted therapy. Towards this goal\, we identified ATP-sensitive potassium channels and Stanniocalcin-1\, two key molecules involved in IOP regulation but with very different mechanisms of action. My talk will describe our adventure (and tribulations) in developing therapeutics\, seeing them through preclinical and safety studies\, and will discuss key steps necessary to get drugs from the bench to the bedside in an academic setting. \n \n \n \n \n \n Bio\n \n \n \n \n \n Dr. Mike Fautsch is the Joseph E. and Rose Marie Green Professor of Visual Sciences at the Mayo Clinic in Rochester\, MN. He is a molecular biologist with an active research laboratory probing the pathogenesis of glaucoma. Dr. Fautsch has devoted his research efforts to understanding the physiology of elevated intraocular pressure regulation\, which is the most prevalent and only treatable risk for the disease. Toward this understanding\, his laboratory team utilizes numerous in vitro\, ex vivo and in vivo model systems to study the molecular and cellular changes that occur in normal and glaucomatous eyes during elevated pressure\, and more recently has developed several new pressure-lowering therapeutics\, one of which is in phase 2 clinical trials. Dr. Fautsch has published nearly 120 peer-reviewed papers\, has received the Ruth Salta Young Investigator award\, the Lew Wasserman Mid-career scientist award\, obtained multiple National Eye Institute and foundational grants to support his research\, and co-chaired several international conferences on the aqueous humor outflow pathway. He earned his undergraduate degree from St. Johns University\, his PhD degree from Mayo Clinic College of Medicine\, and completed his postdoctoral fellowships from UC San Diego and Mayo Clinic College of Medicine and Science. URL:https://doheny.org/event/a-tale-of-two-drugs-developing-novel-therapeutics-to-treat-glaucoma-michael-fautsch-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2022/07/Michael-Fautsch-10335536.jpg ORGANIZER;CN="Janet DeMint & Kaustabh Ghosh%2C PhD":MAILTO:jdemint@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20221202T120000 DTEND;TZID=America/Los_Angeles:20221202T130000 DTSTAMP:20260825T035746 CREATED:20220720T235231Z LAST-MODIFIED:20221031T231328Z UID:10000187-1669982400-1669986000@doheny.org SUMMARY:Inside Out: Relations Between the Microbiome\, Eye Health and Diabetic Retinopathy - Maria Grant\, MD\, FARVO DESCRIPTION:Abstract\n \n \n \n \n \n Diabetic retinopathy (DR) is a complex disease with increasing numbers of individuals being afflicted and treatment modalities limited. There are strong interactions between the metabolome and gut microbiota\, and both have roles in the pathogenesis of DR. Communication axes exist between the gut microbiota and the eye\, therefore\, knowing how the microbiota influences the host metabolism during health and diabetes could guide a better understanding of retinopathy pathogenesis. While considerable experimental evidence exists for a gut–eye axis from murine models of human ocular diseases\, human microbiome-metabolome studies are needed to elucidate changes in the gut microbiome at the taxonomic and functional levels that are functionally related to ocular pathology. This presentation will discuss new ways to diminish DR using genetically modified bacteria that target the renin angiotensin system and using stem cells to increase the integrity of the gut barrier. \n \n \n \n \n \n Bio\n \n \n \n \n \n Dr. Grant is the Eivor and Alston Callahan\, M.D.\, Endowed Chair in Ophthalmology at the University of Alabama\, Birmingham and a Fellow of ARVO. She is globally known for her discoveries related to the functional processes of stem cells (hematopoietic\, embryonic\, and induced pluripotent) and their potential to prevent or repair vascular degeneration in retinopathies associated with diabetes and hypoxia. More recently\, her work has focused on understanding the gut-eye axis\, particularly the link between gut barrier function and disruption of the blood retinal barrier in diabetes. Dr Grant’s research is currently funded by five R01 grants from NEI/NIH while her work has also been supported by the Juvenile Diabetes Research Foundation and the American Heart Association. Her prolific publication record includes over 260 peer-reviewed research articles and 12 reviews and book chapters that have been cited over 21\,000 times. She has also given more than 80 invited lectures about her work all over the world. Dr Grant has been involved with 10 clinical trials related to the treatment of diabetic complications and currently has 13 issued and pending US and international patents. She currently serves on the Editorial Board of IOVS and American Heart Journal Plus: Cardiology Research and Practice. Dr Grant earned her undergraduate and medical degrees from the University of Florida\, Gainesville\, and completed her research fellowships from the University of Florida and the Johns Hopkins University. URL:https://doheny.org/event/inside-out-relations-between-the-microbiome/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2022/07/maria-grant.jpg ORGANIZER;CN="Janet DeMint & Kaustabh Ghosh%2C PhD":MAILTO:jdemint@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20221007T120000 DTEND;TZID=America/Los_Angeles:20221007T130000 DTSTAMP:20260825T035746 CREATED:20220720T233836Z LAST-MODIFIED:20220928T142454Z UID:10000186-1665144000-1665147600@doheny.org SUMMARY:Distinguished Lecture Series - OCT Angiography and Beyond DESCRIPTION:Abstract\n \n \n \n \n \n Optical coherence tomographic angiography (OCTA) is the most important new clinical OCT technology in the past decade. It became available as a clinical instrument in 2014. Since then it has been applied to a wide range of retinal and optic nerve diseases. This presentation will review the current state of the art and key clinical applications. I will also report on the development of several novel OCT technologies in our laboratory that may have important clinical applications in the near future. \n\n One of the important recent advances in OCTA was the development of algorithms to reduce projection artifacts. Projection-resolved OCTA allows visualization of 4 distinct retinal vascular plexuses and improves the diagnosis and classification of optic nerve diseases that primarily affect the superficial plexuses\, outer retinal diseases that primarily affect the deeper plexuses\, and vascular diseases that affect all plexuses. \n\nOne killer app for OCTA is imaging of choroidal neovascularization (CNV). OCTA can visualize CNV below the retinal pigment epithelium better than fluorescein angiography (FA). It is now common to detect CNV that is invisible on FA and shows no retinal fluid accumulation on structural OCT. It may be important to monitor the vessel area of these nonexudative CNV\, which often experience rapid geometric growth prior to the development of exudation and vision loss. In some diseases such as central serous chorioretinopathy (CSR)\, OCTA is useful in distinguishing fluid accumulation due to CSR versus secondary CNV. \n\nThe evaluation of diabetic retinopathy is another emerging application for OCTA. OCTA is able to quantify macular and foveal ischemia\, which may serve as prognostic and pharmocodynamic marker for emerging treatments. OCTA can detect preretinal neovascularization with high sensitivity and measure their vessel area. Widefield OCTA may be useful in the early detection of proliferative diabetic retinopathy and monitoring of treatment efficacy. \n\nUltrawide-field OCT can image almost the entire retina or the ocular surface. Applications in retinopathy of prematurity\, peripheral retinal pathologies\, and corneoscleral topography will be discussed. On the other end of the spatial scale\, OCT microscopy using short wavelength light (i.e. blue or green) can visualize very small structures such as bacteria and collagen lamellae. Early in vitro results will be shown. Finally\, novel contrasts such as directional OCT and OCT oximetry are progressing toward clinical application. Preliminary results in human and rodents will be shown.\n \n \n \n \n \n Bio\n \n \n \n \n \n Dr. Huang is the Associate Director and Director of Research of Casey Eye Institute\, and the Peterson Professor of Ophthalmology and Professor of Biomedical Engineering at the Oregon Health & Science University. He leads the Center for Ophthalmic Optics and Lasers (www.COOLLab.net) that conducts research on topics ranging from the development of novel instrumentation and algorithms to clinical studies in a wide variety of ophthalmic and neurological diseases. Dr. Huang is globally known for his innovations in applying laser and optical technology to eye diseases. He is a co-inventor of optical coherence tomography (OCT)\, a commonly used ophthalmic imaging technology with 30 million procedures performed annually worldwide. His seminal article on OCT\, published in Science in 1991\, has been cited more than 17\,000 times. He has 38 issued US patents in the areas of OCT\, OCT angiography\, mobile health testing\, tissue engineering\, and laser surgery. \n\nHis research\, funded by the NIH\, has been published in more than 300 peer-reviewed articles with over 55\,000 citations. Dr. Huang has received numerous awards throughout his career\, most notable being the Champalimaud Vision Award\, the Friedenwald Award from ARVO\, the Russ Prize from the National Academy of Engineering\, and the Visionary Award from the Greenberg Prize to End Blindness. He is a cofounder of Gobiquity\, maker of the GoCheck Kids app that has screened more than 5 million preschool children for amblyopia risk factors. Dr Huang also has a clinical practice in cornea and refractive surgery. He earned his BS and MS degrees in electrical engineering from MIT\, and MD-PhD degrees from the joint Harvard-MIT Health Sciences and Technology Program. He received ophthalmology residency training at the Doheny Eye Institute/University of Southern California and fellowship training in cornea and refractive surgery at Emory University. \n \n RSVP URL:https://doheny.org/event/distinguished-lecture-series-david-huang-md-phd/ LOCATION:Doheny Eye Institute\, 150 North Orange Grove Blvd. Rm 264\, Pasadena\, CA\, 91103\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/png:https://doheny.org/wp-content/uploads/2022/07/DLS-Huang-1.png ORGANIZER;CN="Janet DeMint & Kaustabh Ghosh%2C PhD":MAILTO:jdemint@doheny.org GEO:34.1488792;-118.1594996 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264 Pasadena CA 91103 United States;X-APPLE-RADIUS=500;X-TITLE=150 North Orange Grove Blvd. Rm 264:geo:-118.1594996,34.1488792 END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20201007 DTEND;VALUE=DATE:20201009 DTSTAMP:20260825T035746 CREATED:20220717T182349Z LAST-MODIFIED:20220721T001345Z UID:10000185-1602028800-1602201599@doheny.org SUMMARY:UCLA Department of Ophthalmology Annual Seminar DESCRIPTION:Course Description\n \n \n \n \n \n The UCLA Department of Ophthalmology Annual Seminar is designed as an update course covering current clinical and research aspects of each of the ophthalmic subspecialties. The 1.5 day program includes the full-time faculties of both the Stein Eye Institute and the Doheny Eye Institute\, along with nationally prominent invited lecturers. The sessions will address current best practices in management\, advanced surgical techniques\, latest diagnostic technology\, and translational re¬search\, in multiple educational formats\, including didactic lecture\, panel discussion\, and case-based interactive presentations. \n \n Register Here URL:https://doheny.org/event/ucla-department-of-ophthalmology-annual-seminar/ LOCATION:UCLA Stein Eye Institute\, 100 Stein Plaza Driveway\, Los Angeles\, CA\, 90095\, United States CATEGORIES:Distinguished Lecture Series ATTACH;FMTTYPE=image/jpeg:https://doheny.org/wp-content/uploads/2021/10/shutterstock_538251463-scaled.jpg ORGANIZER;CN="Doheny Eye Institute":MAILTO:info@doheny.org GEO:34.0649352;-118.4438835 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=UCLA Stein Eye Institute 100 Stein Plaza Driveway Los Angeles CA 90095 United States;X-APPLE-RADIUS=500;X-TITLE=100 Stein Plaza Driveway:geo:-118.4438835,34.0649352 END:VEVENT END:VCALENDAR