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LHON Forum 2022

Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264, Pasadena, CA, United States

Leber hereditary optic neuropathy (LHON) is a blinding mitochondrial disease that disproportionately affects young men. The diagnosis can be challenging with significant delays before a confirmed molecular diagnosis is reached. In this LHON Forum, we will discuss exciting developments in the field highlighting how a deeper understanding of the pathological mechanisms contributing to retinal ganglion cell loss is shaping the therapeutic landscape for this inherited optic nerve disorder.

Register for the LHON Forum 2022, November 28 at 20:00 hrs CET (11:00 am PST)
Register by contacting Gerard Bienfait at
A live broadcast from Doheny Eye Institute, Pasadena USA
Title: The current state of understanding and treatment for LHON

Block 1
Chair: Professor Patrick Yu Wai Man (Cambridge, UK)
Genetics: Professor Valerio Carelli (Bologna, Italy)
Mechanisms/pathways: Professor Alfredo A. Sadun (Los Angeles, USA)
Diagnose: Dr. Chiara La Morgia (Bologna, Italy)
Discussion

Block 2

Chair: Professor Patrick Yu Wai Man (Cambridge, UK)
LEROS: Professor Thomas Klopstock (Munich, Germany)
Gene therapy: Professor Nancy Newman (Atlanta, USA)
Window of opportunity/ chronic patients: Professor Marcela Votruba (Cardiff, UK)
Discussion

Inside Out: Relations Between the Microbiome, Eye Health and Diabetic Retinopathy – Maria Grant, MD, FARVO

Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264, Pasadena, CA, United States

Dr. Maria Grant is the Eivor and Alston Callahan, M.D., Endowed Chair in Ophthalmology and Professor, Department of Ophthalmology and Visual Sciences, at the University of Alabama at Birmingham School of Medicine. Most recently, she has worked on understanding the interactions between the gut microbiome, plasma microbiome, and bacterial derived peptides and metabolites on diseases of the eye and on pathogenesis of severe COVID infection.

A Tale of Two Drugs: Developing Novel Therapeutics to Treat Glaucoma – Michael Fautsch, PhD

Doheny Eye Institute 150 North Orange Grove Blvd. Rm 264, Pasadena, CA, United States

Dr. Michael Fautsch is the Joseph E. and Rose Marie Green Professor of Visual Sciences, 2020 and Research Chair, Department of Ophthalmology at the Mayo Clinic, Rochester, MN. His laboratory team is identifying new therapeutic targets and developing novel therapeutics to regulate pressure and preserve the function of the optic nerve, the ultimate site of eye damage leading to vision loss in glaucoma.