Salary Range: $22.22 – 28.21/hour; Full-time Monday – Friday

Position Summary:  The Ferrington laboratory is seeking energetic and creative candidates to join our team in investigating mechanisms and therapeutic strategies in age-related macular degeneration. This position will collaborate with principal investigator and other laboratory researchers to plan, design, and conduct highly technical and complex research projects. Research in Ferrington lab investigates oxidative stress related mitochondrial dysfunction in cell of the retinal pigment epithelium (RPE) as they relate to age-related macular degeneration.

Principal duties:

1. Conducts research experiments in accordance with laboratory and safety protocols, laboratory procedures and techniques, including but not limited to: (Percentage of time: 70%)
   • Preparing experimental reagents and buffers
   • Cell culture using induced pluripotent stem cells (iPSC) and iPSC-retinal pigment epithelium (RPE)
   • Western blotting
   • Immunostaining/ Histology
   • ELISA
   • Quantitative PCR
   • Mitochondria functional assays
2. Maintains accurate records of procedures used to conduct experiments. Provide data summaries for review by supervisor. (Percentage of time: 10%)
3. Provides input and updates on progress of research and makes recommendations for modification as appropriate. (Percentage of time: 5%)
4. Coordinates and organizes laboratory: monitoring consumable stocks and cell inventory, freezer organization and data storage, maintenance of cell culture equipment (Percentage of time: 15%)
5. Perform all tasks in a safe and timely manner in compliance with safety policies and according to hazardous materials regulations; maintains a neat workstation and environment. (Percentage of time: ongoing)
6. Perform special projects or other related work as required or requested. (Percentage of time: Ongoing)

Qualifications:

• Bachelor’s degree in biological science or related science required.
• Knowledge in biological science-related field required.
• Experience in sterile techniques and culturing cells required.
• Lab experience working in molecular biology or biochemistry preferred, but not required.

To Apply: Please complete the Employment Application and submit to
Opened as of: October 29, 2024

Position Title: Research Fellow
Salary: Self-funded

Full time (Hybrid) Voluntary (must be self-funded).  Support research activities conducted at Doheny Eye Institute.  Provide general assistance to support research activities. Conduct research experiments in accordance with Standard Operating Procedures (SOP) and Institutional Review Board (IRB) protocols. Perform assignments that are non-routine and vary in complexity with general direction.  Compiles data and computes results for a variety of research procedures, tests and techniques. M.D. or Ph.D. required with 1 – 3 years research experience in related field or specialty.

To Apply: Please complete the Research Fellowship Application form and submit to .

Position Summary: Lead projects centered on the development of innovative adaptive optics retinal imaging technologies aimed at enhancing the study of higher-order retinal hemodynamics in the human eye.

Principal duties:

• Optical System Design: Design a new generation of high-speed, high-resolution adaptive optics scanning ophthalmoscope for imaging retinal blood flow in the living human eye.
• Adaptive Optics Development: Develop novel adaptive optics systems to achieve (near) diffraction-limited imaging performance in the living human eye.
• Instrument Assembly: Assemble and integrate optical, mechanical, and electrical/electronic components to construct a clinically deployable imaging system.
• Project Leadership: Lead the project team to achieve key milestones and deliverables within project timelines.
• Scholarly Publication: Document and publish engineering and scientific achievements in peer-reviewed journals.

Qualifications:

• Educational Background: PhD in Optical Engineering, or Electrical Engineering, or Vision Science, or a related field.
• Optical System Design: Demonstrated experience using optical design software (e.g., Zemax) to design and optimize optical imaging system.
• Instrumentation: Practical skills in aligning, assembling, calibrating, and maintaining optical instruments, demonstrating a capacity to handle complex optical systems effectively from conceptualization through to operational deployment.

Desired Skills:

• Experience in adaptive optics, scanning laser ophthalmoscopy/microscopy, or optical coherence tomography, microscopy.
• Strong background in the control of optical and electronic devices, including experience with scanning systems, cameras, and frame grabbers.

Application: Interested candidates should submit a statement of interest, a detailed curriculum vitae, and contact information for two to three references via email to Dr. Yuhua Zhang at . Review of applications will continue until the positions are filled.

Position Title: Research Fellow – Software Engineering
Salary Range: $61,008 – $74,088/year for MD, PhD, inclusive of comprehensive benefits. This range may differ based on education and experience. 

Position Summary: Lead projects centered on the development of innovative adaptive optics retinal imaging technologies aimed at enhancing the study of higher-order retinal hemodynamics in the human eye.

Principal duties:

• Software Development: Develop software for controlling adaptive optics and the imaging system, including real-time image acquisition.
• Project Leadership: Lead the project team to achieve key milestones and deliverables within project timelines.
• Scholarly Publication: Document and publish engineering and scientific achievements in peer-reviewed journals.

Qualifications:

• Educational Background: BS, MS, or PhD in Computer Science, Vision Science, or a related field.
• Programming: Proficiency in programming, and experience in Microsoft Visual Studio C++ for real-time instrument (camera, data acquisition) control is highly desirable.

Desired Skills:

• Strong background in the control of optical and electronic devices, including experience with scanning systems, cameras, and frame grabbers.
• Sound knowledge of analog/digital circuits or field-programmable gate arrays (FPGA) for instrument control and data/image acquisition.

Application: Interested candidates should submit a statement of interest, a detailed curriculum vitae, and contact information for two to three references via email to Dr. Yuhua Zhang at . Review of applications will continue until the positions are filled.

Salary Range: $20.00 – $21.54/hour; Full-time Monday – Friday (Remote)

Position Summary: Serves as Ocular Disease Evaluator (ODE) on assigned DIRC projects. Evaluates digital ophthalmic images on a computer screen and identifies/characterizes ophthalmic features and pathologies in support of medical research activities.  Completes DIRC’s Evaluator Training program.

Principal duties:

• May perform junior or senior evaluator assessment in any Disease Section for which junior or senior evaluator certification has been attained.
• Maintains up to date knowledge of standard grading protocols, and is highly familiar with study-specific grading protocols for assigned studies
• Maintains up to date knowledge of current grading protocols, and best grading practices as defined by the ODE Manager and Principal Investigator (PI) or Medical Director.
• Understands DIRC proprietary grading software programs and successfully operates them in the conduct of grading activities.
• Checks workload daily and prioritizes cases according to the DIRC Standard Operating Procedures.
• Completes cases in a timely manner to ensure turnaround times are met.
• Adheres to the DIRC SOP in the process of grading, routing of cases, and adjudication.
• Generates reproducible grading answers as measured by the DIRC QA re-grading process.
• Notifies ODE Manager, Project Manager, and PI of any grading protocol deviations.  Immediately reports all potential Significant Medical Findings (SMFs) to the ODE Manager and PI.
• Reviews grading materials prepared by the Project Manager/Study Coordinator and returns materials for resolution as needed.
• Adheres to Good Clinical Practice (GCP) documentation procedures in the recording of study data.  Exhibits a low (<2%) error rate in transcription and all manner of data recording.
• Contributes to the improvement of grading software programs by suggesting changes to improve quality and efficiency.
• Other duties as assigned by the ODE Manager.  May include both project support tasks and general operations support.

Qualifications:

• High School or GED required.
• Bachelor’s Degree preferred.
• 2-3 years of progressively responsible work experience, preferably in a research or medical setting.
• Interest in medical research is a must.
• Knowledge of clinical trials helpful, such as completion of a Clinical Research Associate training course or relevant work experience.
• Interest or experience in photography or the visual arts is a plus.

To Apply: Please complete the Employment Application and submit to
Opened as of: August 6, 2024

Salary Range: $20.51 – $21.54/hour; Full-time Monday – Friday (Remote)

Position Summary: Provides Quality Control (QC) responsibilities for DIRC. Follows and maintains current knowledge of departmental policies and procedures.

Principal duties:

• Perform QC review of source documents for completeness, consistency, and adherence to internal and external policies on Good Clinical Practice (GCP), Good documentation Practices (GDP).
• Coordinate closely with individual staff members and groups to communicate negative findings / errors derived from processing of cases, and educate staff on proper procedure.
• Under the general supervision of the Quality Assurance Manager, assist with audit preparation, in organizing personnel training records, and other documentation to ensure their accuracy and completeness.
• Perform other tasks as assigned to support the quality assurance efforts within the DIRC.   
• Other duties as assigned by the Quality Assurance Manager. May include both project support tasks and general operations support.

Qualifications:

• High School or GED required.
• AA or Bachelor’s Degree preferred.
• Experience working in a clinical research environment preferred.
• Previous experience in a quality control function is preferred.

To Apply: Please complete the Employment Application and submit to
Opened as of: August 6, 2024

Salary Range: $17.50 –  $18.50/hour; Full-time Monday – Friday
Position Summary: Provide housekeeping services to Doheny Eye Institute.

Principal duties:

• Perform day-to-day housekeeping functions as assigned to ensure that the facility is maintained in a clean, safe, and comfortable manner.
• Clean/polish furnishings, fixtures, ledges, etc.
• Clean and sanitize restroom fixtures, hardware, partitions, floors, etc.
• Clean windows/mirrors in the restrooms and entrance/exit ways.
• Clean floors, to include sweeping, dusting, damp/wet mopping, stripping, waxing, and buffing as scheduled.
• Clean walls and ceilings by washing, wiping, dusting, spot cleaning, etc.
• Clean hallways, stairways, and elevators.
• Care for and clean the grounds as scheduled.
• Discard waste/trash into proper containers and reline trash receptacles.
• Assure that work/assignment areas are clean and that equipment, tools, supplies, etc. are properly stored at all times, as well as before leaving such areas for breaks, meal times and end of the work day.
• Relieve, assist, or fill in temporarily on other jobs as assigned by the supervisor.
• Set up tables, chairs, and meeting rooms as directed.
• Assure that assigned work areas are maintained in a clean, safe, comfortable, and attractive manner.
• Report any damage or unsafe conditions to facility property as directed.
• Keep work/assignment areas free of hazardous objects such as protruding map/broom handles, unnecessary equipment, supplies, etc.
• Assure that equipment is cleaned and properly stored at the end of the shift.
• Keep supervisor informed of supply needs.
• Performs special projects or other related work as required or assigned.

Qualifications:

• High School or GED required.
• Six months of experience preferred.
• Must possess the ability to make independent decisions, to follow instructions, and to accept constructive criticism.
• Be able to Sit, stand, bend, lift, and move intermittently throughout the workday.
• Is subject to frequent interruptions and may need to reschedule cleaning activities.
• Must be able to lift, push, pull, and move equipment, supplies, etc.

To Apply: Please complete the Employment Application and submit to