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Leber hereditary optic neuropathy (LHON) is a blinding mitochondrial disease that disproportionately affects young men. The diagnosis can be challenging with significant delays before a confirmed molecular diagnosis is reached. In this LHON Forum, we will discuss exciting developments in the field highlighting how a deeper understanding of the pathological mechanisms contributing to retinal ganglion cell loss is shaping the therapeutic landscape for this inherited optic nerve disorder.
Register for the LHON Forum 2022, November 28 at 20:00 hrs CET (11:00 am PST)
Register by contacting Gerard Bienfait at
A live broadcast from Doheny Eye Institute, Pasadena USA
Title: The current state of understanding and treatment for LHON
Block 1
Chair: Professor Patrick Yu Wai Man (Cambridge, UK)
Genetics: Professor Valerio Carelli (Bologna, Italy)
Mechanisms/pathways: Professor Alfredo A. Sadun (Los Angeles, USA)
Diagnose: Dr. Chiara La Morgia (Bologna, Italy)
Discussion
Block 2
Chair: Professor Patrick Yu Wai Man (Cambridge, UK)
LEROS: Professor Thomas Klopstock (Munich, Germany)
Gene therapy: Professor Nancy Newman (Atlanta, USA)
Window of opportunity/ chronic patients: Professor Marcela Votruba (Cardiff, UK)
Discussion
Dr. Maria Grant is the Eivor and Alston Callahan, M.D., Endowed Chair in Ophthalmology and Professor, Department of Ophthalmology and Visual Sciences, at the University of Alabama at Birmingham School of Medicine. Most recently, she has worked on understanding the interactions between the gut microbiome, plasma microbiome, and bacterial derived peptides and metabolites on diseases of the eye and on pathogenesis of severe COVID infection.