By: Peng Shang, PhD, Martin David Harp, Hattie Hayes
At ARVO 2025, in Salt Lake City, Utah, Peng Shang, PhD, talked about her presentation on how the Y402H polymorphism of Complement Factor H (CFH), a major genetic risk factor for AMD, and chronic oxidative stress affect the lipid profile of retinal pigment epithelial (RPE) cells.
The below transcript has been lightly edited for clarity.
Peng Shang, PhD:
Hi. My name is Peng Shang, and I’m from Doheny Eye Institute. I’m actually a Doheny scientist. I work in the parent lab, and I work on age-related macular degeneration. So my presentation at ARVO this year is actually on how the cigarette smoke extract, and then the CFH polymorphism influence the lipid metabolism in the RPE, and then to evaluate how they are involved in the AMD pathogenesis.