Ferrington Lab Group
Our research team has been investigating critical questions driving the field of AMD. What are the cellular changes that occur with aging? What factors “tip the balance” to pathology? How does the cell respond to disease? How can we protect against pathologic changes? To answer these questions, we use tissue and cultured primary retinal pigment epithelial (RPE) cells from human eyebank donors graded for the presence and severity of AMD. We also use RPE differentiated from induced pluripotent stem cells (iPSC-RPE) generated from both eyebank donors and AMD patients. These model systems allow us to investigate the underlying pathophysiology of AMD and to identify drugs that could be used to treat AMD. Our “systems biology” approach includes coupling biochemical analysis of tissues and cells, molecular and cell biology in the Ferrington laboratory, with work of our multidisciplinary team of collaborators who provide complementary expertise in stem cell biology, global protein analysis using label-free mass spectrometry, and targeted metabolomics.