Kannan Lab

Stephen J. Ryan Initiative for Macular Research
Adjunct Professor of Ophthalmology, Jules Stein Institute
David Geffen School of Medicine, University of California, Los Angeles

Email:
Phone: (323) 342-6691

PhD, University of Kerala
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Research Interests: My research interests center on testing novel endogenous and exogenous therapeutic agents using in vitro and in vivo models of dry AMD and subretinal fibrosis. A primary site of pathology in AMD is the retinal pigment epithelial cell (RPE). RPE biology and how RPE mitochondrial function is modulated during the onset and progression of the disease are of interest to our study. We test several peptides in the form of nanoparticles as potential therapeutics employing human polarized primary RPE cell monolayer cultures and animal models.

Email:
Research Interests: Generation of primary cultured human retinal pigment epithelial cells, polarized RPE for vectorial transport, tissue sectioning, immunofluorescence preparation, and development of animal protocols.

PhD, Ophthalmology, Japan
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 2020.
Email:
Research Interests: I am a clinician working in the Ophthalmology Department at the University in Japan. My research interest includes generating experimental models of proliferative vitreoretinopathy (PVR) and studying mechanisms of retinal detachment, particularly relating to EMT-MET transformation. I am also interested in studying prevention modalities in in vitro systems of human RPE cells and in in vivo models of late neovascular AMD, such as subretinal fibrosis and PVR.

B.S. Genetic Engineering, Sungkyunkwan University, Korea
ASCP-MB(American Society for Clinical Pathology) in Molecular Biology
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Research Interests: My research responsibilities include assisting scientists in Dr. Kannan’s Lab with their experiments on multiple projects. I will maintain RPE tissue culture and perform RT-PCR, Western blotting, and metabolic procedures related to in vitro and in vivo experiments in our lab.