d4a5a598c2410dddc7dbc546b392f291

Sun Lab

Home

Research

Members

Publications

Contact

Publications

  • Ko, MK, H. Shao, H J. Kaplan, and D.Sun. (2021). TLR ligand ligation switches adenosine receptor usage and augmented Th17-promoting effect of BMDCs in experimental autoimmune uveitis. J. Immunol. Submitted.
  • Sun, D., Ko, MK, H. Shao, H J. Kaplan (2021). Adenosine receptor ligation tips the uveitogenic Th1 and Th17 balance towards the latter in experimental autoimmune uveitis-induced mouse. Submitted.
  • Ko, MK, H. Shao, H J. Kaplan, and D.Sun. (2021). “Timing effect” of adenosine-directed immunomodulation on mouse experimental autoimmune uveitis. J.Immunol. In press.
  • Sun, D., Ko, MK, H. Shao, H J. Kaplan (2021). Augmented Th17-stimulating activity of BMDCs as a result of reciprocal interaction between γδ and dendritic cells. Molecular Immunol. 134:13-24
  • Ko, MK., H. Shao, HJ. Kaplan, D. Sun, Deming2020. CD73(+) Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice. Front Immuno. 11: 601272.
  • Lu, X., N, Li, L. zhao, D. Guo, H. Yi, D. Sun, H. Nian, R. Wei. 2020. Human umbilical cord mesenchymal stem cells alleviate ongoing autoimmune dacryoadenitis in rabbits via polarizing macrophages into an anti-inflammatory phenotype. Exp. Eye Res. 191: 107905.
  • Zhao,R,J. Qiao,X. Zhang, Y. Zhao, X. Meng, D. Sun, X. Peng (2019). Toll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation. Front. Immunol. 10:2524.
  • Phalke, SP, Y. Huang, K. Rubtsova, A. Getahun, D. Sun, R. Reinhardt, RL. O’Brien, WK. Born (2019). γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice. PLOS ONE. 14: e0218827.
  • Li, X. D. Liang, H. Shao, WK. Born, HL. Kaplan, D. Sun (2019). Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. Cell. Immunol.339:24-28.
  • Nian, H., D.Sun et al. (2019) miR-223-3p promotes autoreactive T h 17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression. FESEB J. 33(12):13951-13965
  • He, Z.,Sun, X.,Ma, Z., Fu, J.,Huang, B.,Liu, F.,Chen, Y.,Deng, T.,Han, X.Sun, D.,Lan, C. 2018. Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal gammadelta T cell’s Th17 response. Cell Biosci.8:38-42.
  • Yun, J., Xiao,T., Zhou,L., Beuerman,RW., Li,J., Zhao,Y., Zhang,X., Sun,D., Kaplan,HJ., and Shao,H. 2018. Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity. IOVS. 59(3): 1332–1342. PMC5846334.
  • Liang,D., H.Shao, WK. Born, RL. O’Brien, HJ. Kaplan, and D.Sun. 2018. High level expression of A2ARs is required for the enhancing function, but not for the inhibiting function, of γδ T cells in the autoimmune responses of EAU. PLoS One. 13: e0199601. PMC6013223.
  • Liang,D., JI Woo, H.Shao, WK. Born, RL. O’Brien, HJ. Kaplan, and D.Sun. 2018. Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on Adenosine. PLoS One. 13: e0197189. PMC5957379.
  • Liang,D., H.Shao, WK. Born, RL. O’Brien, HJ. Kaplan, and D.Sun. 2018. Connection between γδ T cell- and adenosine-mediated immune regulation in the pathogenesis of experimental autoimmune uveitis. Crit. Rev. Immunology. 38:233-143. PMC6361114.
  • Born, W. K., Y. Huang, R. L. Reinhardt, H. Huang, D. Sun, and R. L. O’Brien. 2017. Chapter One – γδ T Cells and B Cells. Adv.Immunol. W. A. Frederick, ed. Academic Press. 1-45.PMID: 28413020.
  • Zhao, Z., Y. Liang, Y. Liu, P. Xu, M. J. Flamme-Wiese, D. Sun, J. Sun, R. F. Mullins, Y. Chen, and J. Cai. 2017. Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury. FASEB J. 2017; 31: 4903–4916. PMC5636697.
  • Yun, J., G. Jiang, Y. Wang, T. Xiao, Y. Zhao, D. Sun, H. J. Kaplan, and H. Shao. 2017. The HMGB1-CXCL12 Complex Promotes Inflammatory Cell Infiltration in Uveitogenic T Cell-Induced Chronic Experimental Autoimmune Uveitis. Front Immunol.8: 142. PMC5306251.
  • Liang,D., Nian, H., Shao,H., Kaplan, HJ., and Sun,D. Functional conversion and dominance of  T subset in mouse experimental autoimmune uveitis. J.Immunol. 2017. 198:1427-1438. PMC5296277
  • Xue,L, Lu,X., Sun,D., Wang,X., Yang,L., Zhao,S., Nian,H., and Wei,R. Adipose-derived mesenchymal stem cells reduce lymphocytic infiltration in a rabbit model of induced autoimmune dacryoadenitis. Invest. Ophthalmol. Vis. Sci. 2016. 157:5161-5170. PMID 27699412.
  • Xiao,Q., Xue,L., Sun,D, Yi, H, Lu,Z., and Nian,H. TLR7 Engagement on Dendritic cells (DCs) Enhances Autoreactive Th17 Responses via Activation of ERK. J.Immunol. 2016. 197:3820-3830. PMID27798152.
  • Zhao,R, Liang,D, and Sun, D. CD73 Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016. 11: e0155953. PMC4873015.
  • Liang,D, Zuo,A, Zhao,R, Shao,H, Born, W., Kaplan,HJ. O’Brien, RL, and Sun, D. 2016. CD73 expressed on γδ T cells shapes their regulatory effect in experimental autoimmune uveitis. PLoS One. 11: e0150078. PMC4769068.
  • Liang,D, Zuo,A, Zhao,R, Shao,H, Kaplan,HJ. and Deming Sun. 2016. Regulation of adenosine deaminase (ADA) on induced mouse experimental autoimmune uveitis (EAU). J.Immunol. 196:2646-54. PMC4779687.
  • Huang, Y, Yang, Z, Huang, C, McGowan,J, Casper,T, Sun,D, Born WK, O’Brien RL. 2015. γδ T Cell-Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis. J.Immunol. 195(12):5572-81. PMC4670787.
  • Jiang,G, Wang,Y, Yun,J, Hajrasouliha,AR, Zhao,Y, Sun,D, Kaplan,HJ, Shao,H.2015. HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent. J Neuroinflammation. 22; 12:179. PMC4579830.
  • Sun,D, Liang,D, Kaplan,HJ, and Shao,H. 2015. The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU). Cytokine. 2015 Jul;74(1):76-80. PMC4457592.
  • Chen M, Liang D, Zuo A, Shao H, Kaplan HJ, Sun D. 2015. An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation. PLoS One, 10: e0132348. PMC4492970.
  • Liang D, Zuo A, Shao H, Chen,M., Kaplan HJ, Sun D. 2015. A2B adenosine receptor activation switches differentiation of bone marrow cells to a CD11c+Gr-1+ dendritic cell subset that promotes the Th17 response. Immunity, Inflammation and Disease. 30;3(4):360-73. (PMC4693722).
  • Liang D, Zuo A, Shao H, M.Chen, Kaplan HJ, Sun D. 2014. The anti- or pro-inflammatory effect of an adenosine receptor agonist on the Th17 autoimmune esponse is inflammatory environmental-dependent. J.Immunol. 193:5498-505. PMC4299924.
  • Liang D, Zuo A, Shao H, M.Chen, Kaplan HJ, Sun D. 2014. Roles of the adenosine receptor and CD73 in the regulatory effect of γδ T cells. PLoS One, 9: e108932. PMC4182534.
  • Aydintug MK, Zhang L, Wang, C., Liang, D., Wands, JM, Michels, AW, Hirsch, B, Day, BJ, Zhang, G, Sun, D., Eisenbarth, GS., O’Brien, RL., Born, WK. 2014. γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation. Molecular Immunology. 60:116-128. PMC4091716.
  • Jiang,G., D.Sun, H.Yang, Q.Lu, HJ. Kaplan, H.Shao. 2014. HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells. J.Leuk.Biol. 95:599-607. PMC3958740.
  • Wei,R., Dong,L., Xiao,L, D. Sun, X.Li., and H, Nian. Engagement of TLR2 enhances IL-17+ autoreactive T cell responses via p38 MAPK signaling in dendritic cells (DCs). 2014. Clin. & Exp. Immunol. 178:353-363.
  • Liang, D., Zuo, A., Shao, H., Born, W.K., O’Brien, R.L., Kaplan, H.J., Sun, D. IL-23 receptor expression on γδ T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis (EAU). J. Immunol. 191:1118-1125, 2013. PMC3720691.
  • Liang, D., A.Zuo, H. Shao, WK. Born, HJ. Kaplan, and D.Sun. 2013. Retinoic acid inhibits experimental autoimmune uveitis via inhibiting CD25+ dendritic cell expansion and γδ T cell activation. Invest.Ophthalmol.Vis.Sci. 54: 3493-3505. PMC3665306
  • Liang, D., Zuo, A., Shao, H., Born, W.K., O’Brien, R.L., Kaplan, H.J., Sun, D. 2013. Retinoic acid inhibits experimental autoimmune uveitis via inhibiting CD25+ dendritic cell expansion and γδ T cell activation. Invest. Ophthalmol. Vis. Sci. 54:3493-3505. PMC3665306.
  • Roark, C.L., Huang, Y., Jin, N., Aydintug, M.K., Casper, T., Sun, D., Born, W.K., O’Brien, R.L. A canonical Vγ4Vδ4+ γδ T cell population with distinct stimulation requirements which promotes the Th17 response. Immunol. Res. Mar;55 (1-3):217-230, 2013. PMC3543513.
  • Huang, Y., Aydintug, M.K., Loomis, J., MacLeod, M.K., McKee, A.S., Kirchenbaum, G., Jakubzick, C.V., Kedl, R.M., Sun, D., Jacobelli, J., O’Brien, R.L., Born, W.K. 1.Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells. J. Immunol.190:913-921, 2013. PMC3552125.
  • Jiang, G., Sun, D., Kaplan H.J., Shao, H. Retinal astrocytes pretreated with NOD2 and TLR2 ligands activate uveitogenic T cells. PLoS One. 7:e40510, 2012. PMC 3393637.
  • Liang, D., Zuo, A. Shao, H., Born, W.K., Kaplan, H.J., Sun, D. Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis (EAU). J. Immunol. 188:5785-5791, 2012. PMC3358586.
  • Zuo, A., Liang, D., Shao, H., Born, W.K., Kaplan, H.J., Sun, D. In vivo priming of IL-17+ uveitogenic T cells is enhanced by Toll ligand receptor (TLR)2 and TLR4 agonists via γδ T cell activation. Mol. Immunol. 50:125-133, 2012. PMC3288362.
  • O’Brien, R.L., Chain, J.L., Kemal Aydintug, M., Bohrer-Kunter, D., Huang, Y., Hardy, I.R., Cambier, J.C., Lahmers, K., Nuhsbaum, T., Davidson, R., Sun, D., Born, W.K. γδ TCR+ T cells, but not B cells, promote autoimmune keratitis in B10 mice lacking gd T cells. Invest. Ophthalmol. Vis. Sci. 53(1):301-308, 2012. PMC 3292366.
  • Nian, H., Liang, D., Zuo, A., Wei, R., Shao, H., Born. W.K., Kaplan, H.J., Sun, D. Characterization of autoreactive and bystander IL-17+ T cells induced in immunized C57BL/6 mice. Invest. Ophthalmol. Vis. Sci. 53:897-905, 2012. PMC 3317428.
  • Ke, Y., Sun, D., Jiang, G., Kaplan, H.J., Shao, H. IL-22–induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis. J. Immunol. 187:2130-2137, 2011. PMC2996892.
  • Ankathatti Munegowda, M., Deng, Y., Chibbar, R., Xu, Q., Freywald, A., Mulligan, S.J., van Drunen Littel-van den Hurk, S., Sun, D., Xiong, S., Xiang. J. A distinct role of CD4(+) Th17- and Th17-stimulated CD8(+) CTL in the pathogenesis of Type 1 diabetes and experimental autoimmune encephalomyelitis. J. Clin. Immunol. 31:811-826, 2011. PMC3275432.
  • Ke, Y., Jiang, G., Sun, D., Kaplan, H.J., Shao, H. Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF- dependent regulatory T cells. Clin. Immunol. 138:311-320, 2011. PMC3046397.
  • Nian, H., Shao, H., O’Brien. R.A., Born, W.K., Kaplan, H.J., Sun, D. Activated γδ cells promote the activation of uveitogenic T cells and exacerbate EAU development. Invest. Ophthalmol. Vis. Sci. 52(8):5920-5927, 2011. PMC3262554.
  • Ke, Y., Sun. D., Jiang. G., Kaplan. H.J., Shao, H. PD-L1hi retinal pigment epithelium (RPE) cells elicited by inflammatory cytokines induce regulatory activity in uveitogenic T cells. J. Leukoc. Biol. 88:1241-1249, 2010. PMC2996892.
  • Nian, H., Shao, H., Zhang, G., Born, W.K., O’Brien, R., Kaplan, H.J., Sun, D. Regulatory effect of γδ T cells on IL-17+ uveitogenic T cells. Invest. Ophthalmol. Vis. Sci. 51:4661-4667. 2010. PMC2941184.