Ruixue Liu, PhD

Dr. Ruixue Liu’s research focuses on developing advanced imaging technologies that allow scientists and physicians to observe the living retina in extraordinary detail, down to individual cells and tiny blood vessels. Using adaptive optics, a technique that corrects for the eye’s natural optical imperfections, he works to produce clearer, more precise images of retinal structures and to measure important aspects of eye health, including blood flow, oxygen levels, and cellular activity. His research also explores how photoreceptors and the retinal pigment epithelium, the cells essential for detecting light and supporting vision, change in age-related macular degeneration and other retinal conditions. By creating better ways to visualize the retina’s structure, function, and metabolism, Dr. Liu aims to detect subtle signs of disease earlier, deepen our understanding of how vision loss develops, and ultimately help clinicians evaluate and treat retinal disease more effectively.

A. RESEARCH PAPERS – PEER REVIEWED

1. R Liu, Y Qi, X Zheng, M Xia, L Xuan, Flood-illuminated adaptive optics ophthalmoscope with a single curved relay mirror, Photonics Research, 2013, 1(3), 124-129
2. X Zheng, R Liu, M Xia, Z Cao, L Xuan, Research on liquid crystal adaptive optical retinal correction imaging technology, Chinese Optics, 2014, 7(1): 98-104
3. X Zheng, R Liu, M Xia, D Li, L Xuan, Temporal properties study of ocular wave aberrations with high frequency sampling, Acta Optica Sinica, 2014, 34(7)
4. R Liu, X Zheng, D Li, M Xia, L Hu, Z Cao, Q Mu, L Xuan, Retinal axial focusing and multi-layer imaging with a liquid crystal adaptive optics camera, Chinese Physics B, 2014, 23 (9), 094211
5. R Liu, X Zheng, M Xia, X Lu, L Xuan, Accurate fixation of adaptive optics fundus imaging field of view based on visual target guidance, Infrared and Laser Engineering, 2015, 44(6),1794-1799
6. B Khoobehi, H Wafapoor, A Eaton, R Liu, K Firn, T Kubilay, Noninvasive measurement of oxygen saturation in human retinal blood vessels and tissues with multispectral confocal imaging, Ophthalmic Surgery, Lasers and Imaging Retina, 2022, 53 (5), 275-283
7. R Liu, X Wang, S Hoshi, Y Zhang, High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy, Optics letters, 2023, 48 (8), 1994-1997
8. R Liu, X Wang, S Hoshi, Y Zhang, Substrip-based registration and automatic montaging of adaptive optics retinal images, Biomedical Optics Express, 2024, 15 (2), 1311-1330
9. X Wang, S Hoshi, R Liu, Y Zhang, Modeling human macular cone photoreceptor spatial distribution, Investigative Ophthalmology & Visual Science, 2024, 65 (8), 14-14
10. X Wang, S Hoshi, R Liu, G Corradetti, M Ip, D Sarraf, SVR. Sadda, Y Zhang, Photoreceptor function and structure in retinal areas with intraretinal hyperreflective foci in age-related macular degeneration, Investigative Ophthalmology & Visual Science, 2025, 66 (2), 27-27
11. R Liu, X Wang, C Soylu, G Corradetti, SVR Sadda, and Y Zhang, Evaluating the influence of the lens autofluorescence on adaptive optics fluorescence lifetime imaging ophthalmoscopy, Translational Vision Science and Technology, 2026, 15(5):17

B. RESEARCH PAPERS – PEER REVIEWED (SUBMITTED)

1. X Wang, S Hoshi, S Kadomoto, R Liu, M Ip, D Sarraf, SVR Sadda, Y Zhang, Cuticular drusen associated photoreceptor and rpe optical property perturbation revealed by adaptive optics scanning laser ophthalmoscopy, American Journal of Ophthalmology, 2026
2. S Hoshi, X Wang, S Kadomoto, R Liu, M Ip, SVR Sadda, D Sarraf, Y Zhang, Early photoreceptor disruption in emerging subretinal drusenoid deposits detected by adaptive optics imaging, Ophthalmology Science, 2026

C. RESEARCH PAPERS (NON-PEER REVIEWED)

1. R Liu, X Wang, C Soylu, G Corradetti, DA Ferrington, SVR Sadda, Y Zhang, Adaptive optics fluorescence lifetime imaging ophthalmoscopy for single-cell–resolved in vivo metabolic and structural imaging of the human retinal pigment epithelium, medRxiv 2026.02.07.26345814